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KMID : 1094020150320060491
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Journal of Veterinary Clinics
2015 Volume.32 No. 6 p.491 ~ p.498
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The Effect of Doxapram on Cardiopulmonary Function in Dogs under Total Intravenous Anesthesia with Remifentanil and Propofol
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Yun Sung-Ho
Kwon Young-Sam
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Abstract
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We investigated the effect of constant rate infusion (CRI) with doxapram on cardiopulmonary function duringtotal intravenous anesthesia (TIVA) with remifentanil and propofol CRI in dogs. Fifteen male Beagle dogs wererandomly divided into 3 groups. All groups were premedicated with medetomidine (20 μg/kg, IV) and anesthetizedby remifentanil/propofol CRI for one and half hour. At the initiating of the anesthesia, different doses of doxapramfor each group were administrated as the followings; D1 group - doxapram 0.25 mg/kg bolus followed by doxapram8.33 μg/kg/min, D2 group - doxapram 2 mg/kg bolus followed by doxapram 66.66 μg/kg/min, control group - normalsaline. The anesthetic depth for surgery was well maintained in all groups throughout the anesthetic periods. Therespiratory rate was significantly higher in D2 group than that of control group (p < 0.05). The values of PaO2 andSaO2 were significantly increased in both D1 and D2 groups compared with control group (p < 0.05). High dose ofdoxapram (D2 group) significantly decreased the level of PaCO2 compared with control group (p < 0.05). The valuesof systolic, mean and diastolic arterial pressure were significantly increased in doxapram 2 group (p < 0.05). Therewere no significant differences in the values of heart rate and pH of arterial blood. Therefore, doxapram CRI maybe useful to alleviate the suppression of cardiopulmonary function including hypoxia and hypotension during TIVAwith remifentanil and propofol in dogs.
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KEYWORD
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dog, doxapram, propofol, remifentanil, TIVA
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